This Baked Cajun Salmon with Creamy Avocado Lime Sauce is the perfect weeknight dinner—packed with bold flavors, ready in under 30 minutes, and loaded with healthy fats and protein. The spicy Cajun seasoning pairs beautifully with the cooling, zesty avocado lime sauce, making each bite a flavor explosion. Whether you’re looking to impress guests or simply upgrade your dinner routine, this dish delivers.
Why You’ll Love This Recipe
- Fast and easy: Ready in just 25 minutes with minimal prep.
- Healthy: Rich in omega-3s, protein, and heart-healthy fats.
- Bold flavor: Spicy Cajun seasoning contrasts perfectly with the creamy, tangy sauce.
- Versatile: Serve with rice, quinoa, roasted veggies, or a simple side salad.
- Great for meal prep: Make ahead and refrigerate for up to 3 days.
Ingredients
For the Salmon
- 4 salmon fillets (about 6 oz each, skin-on or skinless)
- 2 tablespoons Cajun seasoning
- 1 tablespoon olive oil
- Salt and pepper (to taste)
For the Creamy Avocado Lime Sauce
- 1 ripe avocado
- 1 lime (juiced)
- ¼ cup Greek yogurt
- 1 clove garlic (minced)
- Salt (to taste)
- Fresh cilantro (optional, for garnish)
How to Make Baked Cajun Salmon with Avocado Lime Sauce
- Preheat your oven to 400°F (200°C). Line a baking sheet with parchment paper or foil for easy cleanup.
- Pat the salmon fillets dry with a paper towel. Drizzle with olive oil and rub in the Cajun seasoning, salt, and pepper to coat evenly.
- Place the fillets on the prepared baking sheet. Bake for 12–15 minutes, or until the salmon flakes easily with a fork.
- While the salmon bakes, prepare the avocado lime sauce: In a blender or food processor, combine the avocado, lime juice, Greek yogurt, garlic, and salt. Blend until smooth and creamy. Add a splash of water if needed to thin the sauce to your desired consistency.
- Plate the salmon fillets and drizzle generously with the creamy avocado lime sauce. Garnish with chopped cilantro, if using. Serve immediately.

Serving Suggestions
- Serve over a bed of rice, quinoa, or cauliflower rice.
- Pair with roasted vegetables like asparagus, broccoli, or bell peppers.
- Add to tacos or wraps for a spicy, creamy seafood twist.
Tips for Success
- Use fresh salmon: Wild-caught salmon delivers the best flavor and texture.
- Don’t overcook: Salmon is done when it flakes easily and is still moist in the center.
- Customize the heat: Adjust the Cajun seasoning to your spice preference, or add a pinch of cayenne for extra heat.
- Make it dairy-free: Use a dairy-free yogurt alternative in the sauce.
Storage & Reheating
- Store: Keep leftovers in an airtight container in the fridge for up to 3 days.
- Reheat: Warm salmon gently in the oven at 300°F or microwave in short intervals to avoid drying out. The avocado sauce is best served fresh but can be stored separately for 1 day.
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Final Thoughts
This Baked Cajun Salmon with Creamy Avocado Lime Sauce is a go-to recipe for busy nights when you want something nutritious, flavorful, and fast. It’s a restaurant-quality meal made right in your own kitchen—without the fuss. Try it once, and it’ll be on repeat in your weekly dinner rotation.